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These data underline the current concept proposing that TLRs play a central role in the pathogenesis of a number of kidney disease [44], [45].
More recently, we further developed this concept, proposing that thymocyte migration is actually derived by a resulting migration vector, which in turn appears as a consequence of various migration vectors (each one corresponding to a given ligand/receptor pair interaction) that can differentially contribute to generating the resulting migration vector [29], [30].
The long recognized association between cardiovascular disease and obesity [ 2] became clearer in 1988 when Reaven [ 3] consolidated the concept proposing that insulin resistance with compensatory hyperinsulinemia was a fundamental pathogenetic mechanism.
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Clements' superorganism concept proposed that ecosystems progress through regular and determined stages of seral development that are analogous to the developmental stages of an organism.
This concept proposes that redundant mechanisms are available to bring about normal repolarization; therefore, to elicit the full-blown LQTS phenotype multiple hits might be required to sufficiently reduce the reserve (Roden, 2006).
The fetal programming concept proposes that environmental factors operating during the peri-conceptional and fetal periods affect the propensity to diseases in adulthood (Gluckman and Hanson, 2006; Harris and Seckl, 2011).
This concept proposed that the most plesiomorphic taxa in a cladogram would be situated in a hypothesized geographic centre of origin, while the more derived taxa would be those most distant from the putative center of origin.
The index-lesion concept proposes that it is only the dominant lesion that drives the natural history of the disease [98 101].
This concept proposes that phospho marks permit the docking of methylmark 'readers', allowing gene activation by at least two possible mechanisms.
The hapten/prohapten concept proposes that the drug or its metabolite (hapten/prohapten) reacts with a self-protein through covalent binding to generate a haptenated, de novo product.
The CSC concept proposes that, within a given tumor, a phenotypic hierarchy exists, with a minor subset of the so-called CSCs at the apex and highly proliferating, lineage-committed progenitors and terminally differentiated cells at the base [ 18].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com