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We shall make more precise what we mean by this in Section 1, which discusses the concept of suppression of interference and gives a simplified survey of the theory, emphasising features that will be relevant to the following discussion.
Immunoregulatory CD4+CD25+FoxP3+ T cells (Tregs) have greatly influenced the concept of suppression of immune responses, and are known to inhibit autoimmune diseases [3] [5] and elicit transplantation tolerance [6], [7].
The concept of suppression is often a difficult one for students, but it is worth teaching in some depth.
Although it is easy to understand the concept of suppression as a reversal of a mutant phenotype, understanding mechanisms of suppression is more difficult.
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"Dr. Tada did the pioneering work in bringing forth the concept of immune suppression, which is a fundamental and correct concept in immunology".
However, the concept of active suppression by T cells lost acceptance because of several technical problems.
If, indeed, higher T concentration is required for spermatogenesis than for peripheral androgen actions, then the concept of gonadotropin suppression by exogenous T treatment is feasible.
This concept of "active suppression" is supported by recent findings showing that macrophages produce and release the immunoregulatory cytokines transforming growth factor-beta (TGF-β) and interleukin IL-10 (IL-10) [ 1– 4] when they contact, engulf, and digest apoptotic cells in cell culture.
The concept of a vibration suppression device mounted inside the rotor blade of a helicopter is evaluated.
The concept of the carbonation suppression ratio of paint was presented for evaluation of the anti-carbonation performance of the two types of paints (exterior and interior paints) when applied to a reference concrete substrate.
But when molecular studies with hybrid DNA technology failed to identify the I J region within the MHC [ 6], the concept of T cell suppression was discarded.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com