The concepts of selectivity and additivity fields have been employed in developing selective CoMFA models for these related kinases.
We introduce the concept of selective control or selectivity in cell populations as the requirement of finding a set of inputs which induce one member of the population to produce a desired response while ensuring that the remaining members of the population have a minimal response.
This loss can be reduced by using the concept of directional selectivity in which radiation is suppressed at angles larger than the incident angle of the sunlight striking the absorber.
The fact that Robenacoxib appears to reduce synovial levels of CRP supports a local effect and the concept of tissue selectivity.
This is made more complex by the concept of functional selectivity, also termed ligand or stimulus bias [ 23,24], whereby the signalling outcome of a receptor can be modulated differentially by different ligands.
This has lead to the concept of tissue selectivity [ 4] by which a drug concentrates in the inflamed tissues where it is required and has a prolonged anti-inflammatory effect.
Recently, these concepts have been revised by the introduction of the novel concept of 'functional selectivity', which postulates that a drug may not easily be classified as an agonist or antagonist, but may produce a mix of the classic effects through activation or inhibition of only one or a limited number of signal transduction pathways coupled to the target receptor [ 32, 33].
In this contribution we develop the concept of selective control in diverse cell populations, and introduce computational methods which optimize selectivity for a particular signal for a designated member of a cell population.
Therefore, the concept of tissue-selectivity, which considers those genes whose expression is enriched in one or more similar tissues [6], might be more useful.
"This evolutionary ethic that inevitably takes as its key concept the model of selectivity, that is, the struggle for survival, the victory of the fittest, successful adaptation, has little comfort to offer," he wrote.
