Sentence examples similar to concept of proofreading from inspiring English sources

While our data do not directly challenge the concept of kinetic proofreading, they do show that it is impossible to define an absolute TCR/pMHC off-rate at 25°C for T cell activation across all systems.

Thus, our findings suggest that, at a minimum, the concept of kinetic proofreading requires further refinement to account for the >10-fold difference between agonist TCR/pMHC off-rates in different systems.

Building upon the concepts of kinetic proofreading and our understanding of M.HhaI, we describe how a 16-fold specificity enhancement achieved with a double mutation at the loop/active site interface is acquired through destabilization of intermediates prior to methyltransfer rather than disruption of direct interactions between the enzyme and the substrate for M.HhaI.

State officials conceded that four other mistakes indicated a certain sloppiness or lack of proofreading.

The strain of proofreading his almost illegible handwriting helped ruin her eyesight, too.

Due to the lack of proofreading in RNA-dependent RNA polymerases, RNA viruses have extraordinarily high rates of mutation.

But it seemed to me that assistant editors did lots of proofreading for very little money.

Let this be a lesson in the importance of proofreading.

Loss of proofreading by a replicative polymerase as Polδ increases spontaneous tumour development in mice [43].

For amplification we used the Advantage GC Genomic LA Polymerase Clontech, Bella Avenue Mountain View, California) including a small amount of proofreading enzyme, a hot start antibody and a 3' to 5' proofreading exonuclease activity.

"The Physiocrats' concept of economics".