Sentence examples for concept of essentiality from inspiring English sources
One of the important heuristics based on the concept of essentiality ratio for maximization of throughput and minimization of system unbalance simultaneously was proposed by [Mukhopadhyay et al. (1992)].
However, relying only on the bioinformatic studies, the concept of essentiality of particular replicons is highly speculative, thus to define their nature we applied additional analyses.
Deutscher et al. refer to this generalized concept of essentiality as " k-robustness" in their investigations of multiple knockouts in yeast metabolism [ 1].
The concept of (super)essentiality can be extended to entire metabolic pathways, groups of essential reactions that share substrates/products with each other and cannot be replaced without a loss of viability.
One of the advantages of OGEE is the inclusion of the concept of conditional essentiality (22).
Despite the success of the concept of modular essentiality in explaining the behavior of protein complex subunits, the extensive presence of exceptions is troubling.
The concept of conditional essentiality could explain why Geptop results correlated well with the EC01 and EC02 data sets, but not so well with the EC03 data set.
Following the concept of conditional essentiality, we identified the intersection among the EC01, EC02 and EC03 data sets (and the STY01, STY02 and STY03 data sets) as the universal essential (UE) genes for E. coli (S. typhimurium), whereas the other essential genes were identified as conditional essential (CE) genes.
Here we incorporate the concept of induced-essentiality into drug target discovery by identifying targets that become influential only after the tumors have undergone 14 days or 90 days of letrozole treatment.
This highlights an idea that has recently become the focus of an intense debate (cf. Fine 1994a, 1994b, 1995), namely the idea that the concept of necessity is distinct from that of essentiality and that the latter grounds the former (cf. Mulligan 2004).
In addition to the systematic evaluation of essentiality of signaling components done here, the concept of ESM opens new avenues of research relating the structure and function of signaling networks, as discussed above.
