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The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted much interest.
The impressive results obtained with high dose lympho-myeloablative conditioning regimens are in accordance with the concept that autoimmune diseases are maintained by activated autoreactive T cells which have to be eliminated as thoroughly as possible to achieve complete and lasting remission.
An emerging concept in tumour biology suggests that tumours are maintained by CSCs (Reya et al, 2001; Perez-Caro and Sanchez-Garcia, 2006; Dalerba et al, 2007a).
UMLS is the most extensive known database of synonyms and concepts relations of biomedical and health-related terms, maintained by National Library of Medicine.
The concept applies to cultures in which there is also an urban, technically more sophisticated musical tradition maintained by and for a smaller social, economic, and intellectual elite in cities, courts, or urbanized cultures.
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