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The significance of this concept is substantial because it implies that there was no lineage of eukaryotic-type gene or cell organization that goes all the way back to the origin of life (an assumption implicit in most formulations of introns early).
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"An anorak is substantial.
Yet the gain is substantial.
But the number is substantial.
The lineup is substantial.
"That is substantial funding".
The integration is substantial.
The height effect is substantial.
The taste effect is substantial.
And the difference is substantial.
The potential opportunity is substantial.
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