These data support the current concept for the functional role of MAL in sorting and trafficking of particular components to the plasma membrane (Schaeren-Wiemers et al., 2004).
However, we are reluctant to entirely omit these data, as we believe that the finding represents an important proof of concept for potential functional differences between the two histones at the molecular level, which must be mediated by only five amino acid differences.
Altogether, our studies provide a proof of concept for multiple-functional drug delivery system that based on the specific gene network involved in tumor growth, and highlight the clinical potential of NCL/miR-221/NFκB/DNMT1-targeted NCL/miR-221/NFκB/DNMT1-targeted NCL/miR-221/NFκB/DNMT1-targeted
Our studies demonstrate that minipigs offer an excellent translational model for the concept of functional tooth regeneration and the feasibility of using autologous stem cells for transplantation.
Amundson (2000) goes so far as to deny that there is any biological basis for a concept of functional normality a claim emphatically rejected by Boorse (2010).
The approach is grounded on the concept of functional basis for the analysis of product modules and the theory of Multi Criteria Decision Making (MCDM) approach for the assessment of the best design option.
Similarly to the concept of functional orthology [26], for each of these proteins we assumed that their pathway annotations (i.e., signaling role) can be transferred between species.
A new design strategy, based on the concept of functional composite materials, allows for a greater control over material properties and functions and has shown great promise in designing SMPs for a wide variety of applications.
The concept of stability for functional equation arises when we replace the functional equation by an inequality which acts as a perturbation of the equation.
Scala is a modern multi-paradigm programming language that is fully object-oriented with a strong support for typical concepts from functional programming such as higher-order functions, type inference, and pattern matching.
