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The conventional view is that relevance in law is a binary concept: evidence is either relevant or it is not.
Even though the use of systematic research has deep roots in the history of medicine, the concept "evidence based medicine" (EBM) was first introduced in 1991 by Gordon Guyatt [1].
This investigation provides proof of concept evidence that brief illumination of skin or muscle with non-destructive, safe, green laser can prime the body to a stronger response to a protein prototype vaccine that, by itself, induces relatively weak immune responses.
Supporting this concept, evidence for a relationship between Lewy bodies in the substantia nigra and functional disability has been reported in nondemented older people [ 71].
These preclinical studies have provided proof of concept evidence that exogenous OPCs could enhance remyelination, but whether they can provide clinical benefit remains unknown.
156 This provides proof of concept evidence that the development of celiac disease can be halted, although it is not known whether there is any step beyond which the path is irreversible.
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In this article four descriptive and two normative characteristics of the general concept "evidence-based" are presented and explained systematically.
However, the realist synthesis approach allowed us to populate our framework describing the complex, episode-of-care nature of AH therapy services, with the current quality concept evidence-base, and thus to develop a framework for evaluating AH therapy quality.
Anesthesia-induced change in brain cell architecture provides proof-of-concept evidence for the suitability of the piglet model in neurotoxicity studies.
Thus our study provides proof-of-concept evidence that clinical compounds identified through promoting cell reprogramming efficiency could be applied safely to facilitate tissue regeneration.
Altogether, we demonstrated proof-of-concept evidence for the feasibility, capability and safety of a nanovaccine platform towards efficient personalized anticancer application.
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CEO of Professional Science Editing for Scientists @ prosciediting.com