Interestingly, the λexmax of the graft-copolymers in aqueous solutions displayed a concentration-dependent behavior above a given concentration, which translated into a red-shift of the maximum of excitation when increasing the polymer concentration (SI, Figure S16).
This is an expected consequence of the nominal aqueous phase concentrations, which translate into significant concentrations in the bilayer due to the compounds high partition coefficients into the membrane.
The limitation of Empirical Bayes estimation is that volume of distribution (Vd) cannot be reliably estimated due to the sparse sampling, and therefore, the variation in the observed concentrations is predominantly translated into the variation in clearance.
By extending the constraint-based modeling framework to encompass thermodynamic constraints on Gibbs energies of reactions, knowledge of absolute metabolite concentrations can be translated into constraints on flux directions (Kümmel et al., 2006b; Henry et al., 2007).
Absorption data were translated into NADH concentration using a standard NADH concentration curve.
On the other hand, prior to any intervention the system seems to have lost any potential for attenuation and its inability to adapt to high LPS concentration is mathematically translated into unconstrained responses (dashed lines).
The high precision of classical chemical kinetics arises because the mass action assumption implies that infinitesimal changes in input concentration are instantly translated into a linear change in the rate of collisions between potential reactants.
This attribute may permit attainment of higher plasma concentrations that translate into improved response rates in patients with BCL-2-dependent malignancies.
The model predicts the existence of several dynamic modes of ciliary regulation, such as the generation of intraciliary Ca2+ spike with amplitude proportional to the degree of membrane depolarization, the ability to maintain stable oscillations, monostable multivibrator regimes, all of which are initiated by variability in ionic concentrations that translate into altered membrane voltage.
This concentration could then be translated into the allowable global emission budget.
