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This system simplifies treatment, but it requires high IMZ concentrations to be effective, which result in large amounts of fungicide per unit mass of citrus fruit being applied.
Currently many aggregation inhibitors would need to be used at high concentrations to be effective against the high levels of tau present in neurons [ 70].
The dosage of 1.2 g was selected for the following reasons: 1) it is within the typical dosage utilised in previous literature; 2) a lower dose, divided into multiple capsules, might not reach adequate concentrations to be effective; and 3) concerns that higher doses would reduce CINV control.
The relatively high EC50 does not necessarily indicate a lack of activity because many effective anticancer agents are only active in the millimolar range [ 51], and the low toxicity of these compounds should enable delivery of high enough concentrations to be effective.
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The principle governing the use of antibiotics is to ensure that the patient receives one to which the target bacterium is sensitive, at a high enough concentration to be effective but not cause side effects, and for a sufficient length of time to ensure that the infection is totally eradicated.
Most active agents used for extracerebral non-Hodgkin's lymphomas do not penetrate the blood brain barrier at sufficient concentration to be effective against primary brain lymphoma, and agents that do penetrate the CNS have generally not been very effective, or have caused unacceptable toxicities (Ferreri et al, 2003; Reni and Ferreri, 2004a).
An additional indication for the use of powdered sulfathiazole locally was the considerable evidence to show that pus is a definite depresser on the action of the sulfathiazole group, and that fibrous encapsulation of a focus makes it difficult for the drug to reach the focus through the blood stream in sufficient concentration to be effective.
While many shampoos and conditioners have tea tree oil in them, they are unlikely to have a high enough concentration to be effective.
Therefore, PPADS was infused intracerebroventricularly for 7 days continuously at a concentration shown to be effective on EEG changes in a microdialysis approach of brain injury and in a previous study on the amount of profoundly damaged cells [26], [28].
Under our experimental conditions, 3 μM DSF, which is the lowest concentration reported to be effective in Xoo [ 42], significantly increased swimming of XKK12.
These concentrations were found to be effective against M. smegmatis under in vitro killing assay.
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