Percentage of subjects in the VLCK diet group who presented with alanine aminotransferase or aspartate aminotransferase plasma concentration threefold higher than the upper limit of the normal range was not significantly different compared with controls (0%; P=0.157).
In rats with severe heart failure, the circulating renin-angiotensin system was activated, with an increase in plasma renin activity (3.5-fold, p < 0.05) and plasma angiotensin II concentration (threefold, p < 0.01).
Notably, a substantial excess in RGS concentration (threefold to fourfold), and hence G protein deactivation rates above this threshold, has no influence on ON-BC response properties.
There were differences among the treatments: on day 14, nitrogenous compounds were still abundant in the HA, PGPB, and HA + PGPB treatment exudates; the concentrations were threefold to fourfold higher than those in the control.
Concentrated feed supplements boosted cell concentrations almost threefold and antibody titers up to sevenfold.
Despite hypericin being a stronger photosensitizer, DTHe exhibited advantageous phototoxic properties to tumour cells, initiating apoptosis at concentrations about threefold lower than hypericin.
To determine the in vitro synergy of two drugs they were combined at a constant ratio (based on the individual drug's IC50), with nine concentration steps, threefold dilutions and the highest dose used being 8 × IC50 concentrations.
LLNA-associated data consisted of vehicles, effective concentration for threefold induction of draining lymph node cell proliferation, the result of LLNA, evaluated concentrations and corresponding stimulation index (SI).
Nevertheless, the tight correlation that we observe between P5 and P15 experiments demonstrates that most of the genes undergoing transcriptional changes at a high concentration of paraquat display similar changes (although at a reduced level) when the concentration is threefold lower.
By modeling the space-time yield of the process was nearly doubled and the coenzyme concentration reduced threefold.
