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The testing results showed that the NH4+ concentrations simulated with the VART-NH4 model were in reasonable agreement with those monitored at the wetland outlet, as indicated with the RMSE of 0.06 mg/l.
zileuton doses and 10 (clinically marketed dose of montelukast as Singulair) and 50 mg montelukast doses q.d. Figure 2a – c show the effect of these doses on FEV1, airway eosinophils and extracellular LT concentrations simulated with our model and clinically measured.
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Using the in silico/ in vitro data alone to describe the lung passive permeability within the model the ELF plasma concentrations were simulated with reasonable accuracy (within 2.5-fold) for four of the seven compounds tested and lung tissue:plasma concentration ratios were simulated with reasonable accuracy for four of six compounds.
The accumulated methane production curves for NS1 and NS2 at various I/ S ratio and calcium concentration were simulated with the developed kinetic model (Figs. 2, 3).
Link to figure S1 With acute exposure to luminal glucose to 30mM, as modelled in figure S1 A and B luminal glucose concentration is simulated with an exponential rise with a t ½ ≈ 1-2min.
By inferring the parameters (shown in Figure 5), we constrain the model simulations to realistic behaviours and finite species concentrations (example trajectories simulated with parameters drawn from the posteriors are shown in Figure 6).
Over the 63 days of the experiment, total aqueous Fe and As concentrations were correctly simulated with these parameters for experiments AD5 and CP5 (Fig. 8).
Hourly concentrations of PM10 were simulated with a spatial resolution of 200 × 200 m grid cells for 1990 and 2002.
Concentration-time profiles were simulated with a 4-compartment system (blood, peripheral tissues, BBB endothelium and brain parenchyma).
Within Experiment D the measured concentration of Cu is simulated with a coefficient of determination (r 2) of 0.69 and for Fe with 0.83, which can be considered as a fairly good result.
Therefore, the concentration and activation polarizations are simulated with much less computational work compared to a three-dimensional numerical model.
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