Voltage dependence of NMDA current was simulated by multiplying the command signal by an additional factor (1+0.33[Mg2+]exp(−0.06V))−1 [14], where V is the membrane potential and [Mg2+] is the extracellular magnesium concentration set to 1 mM.
The adenylate cyclase deletion model (cyr1Δ) was simulated with cAMP concentration set to 1.
After 24 h when cell adhesion was achieved, the medium was changed and the serum concentration set to 10, 5 or 2% FCS.
= maximum monthly near-surface chlorophyll a concentration (set to a maximum of 10 mg/m), SSS average = annual average sea surface salinity (SSS, set to a minimum of 30 PSU), PAR max.
Due to the low levels and limited number of samples in which SMT19969 was detected, PK analysis conducted on 'worst case' scenario with plasma concentrations below the limit of quantification (BLQ) from the time of pre-dose sampling (t = 0) up to the time of the first quantifiable concentration set to a value of zero.
Briefly, initial populations of 100, 200, 500 and 700 cell agents were "seeded" on a 1 mm × 1 mm virtual surface and expanded in silico, with the model parameter that represents the extracellular calcium concentration set to either 0.1 mM or 2.0 mM.
Beyond 23 years (the year that surface input concentrations were set to zero) the concentrations decreased to approximately 1.6 mg/L after 73 years which is still above the acceptable limit (Fig. 5).
For a majority of modelling studies the input NO and NO2 concentrations were set to match the experimental concentrations at the initial site.
In the second method, a solution reservoir holding the physiological solution is bubbled to equilibration with vaporized isoflurane and concentrations are set to the desired nominal concentrations by a calibrated vaporizer, e.g. [2].
Nondetectable concentrations were set to the LOQ for concentration ratios.
