Rotenone alone reduced basal cell proliferation, and additional supplementation with IGF-1 could only slightly enhance Ki67-positive cells and BrdU incorporation, indicating that at higher concentrations overwhelmed the cell proliferation stimulatory effect of IGF-1 (Fig 2E and Supplementary Fig S2).
When ROS concentrations overwhelms the antioxidant capacity, oxidative stress is generated with characteristic cell damage.
When Figures 1 and 5 are compared, it is clear that changes in the extrinsic site concentration (doping) overwhelm effects on Ge due to changes in water content.
Mild exposure may cause mild oxidative stress that ignites cellular antioxidant defense systems; exposure to moderate to higher concentrations may gradually overwhelm antioxidant defense systems to induce apoptosis, while exposure to even higher concentrations for long periods may quickly overwhelm antioxidant defenses to stimulate prooxidative effects leading to cellular damage via necrosis.
Although methanol may be toxic to humans at concentrations that overwhelm certain enzymes involved in methanol metabolism, the data available provide little evidence to indicate that exposure to methanol vapors from the use of methanol as a motor vehicle fuel will result in adverse health effects.
Overwhelming evidence reveals that concentrations of dissolved organic carbon (DOC) have increased in streams which brings negative environmental impacts.
Overwhelming cell death could be observed at the concentration of 100 μg/mL, and the migration was difficult to be evaluated.
At low levels, the gas smells like rotten eggs, but at higher concentrations, it can quickly overwhelm.
At higher concentrations, however, pesticides may overwhelm the ability for organisms to upregulate these enzymes or the cost of upregulation may simply be too high; if so, then we would not expect to observe induced tolerance at high pesticide concentrations.
Thus, it is possible that in the experimental studies using PFSPs the natural barriers to induction and spread of αS induction pathology were artificially overwhelmed beyond concentrations that would normally occur.
