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In other words, CLIA is able to determine the presence of antibodies at extremely low concentrations (limit of detection = zeptomole 10−21 mol).
However, several problems, such as low activity and poor stability (poor tolerance to high aldehyde concentrations), limit the practical application of DERA in large-scale production.
Modeled equilibrium with respect to FeIII precipitates varies with pH and Fe and SO42− reconcentrations: increasing pH promotes the formation of ferrihydrite, while decreasing concentrations of Fe limit the formation of ferrihydrite, and decreasing Fe and SO42− concentrations limit the precipitation of schwertmannite and favor formation of FeIII hydroxyl complexes and uncomplexed Fe2+ and Fe3+.
That doesn't mean that lower concentrations limit verbal ability -- a child can potentially lose half her brain and still walking around speaking in complete sentences.
Molecular oxygen has two opposing effects: initially low oxygen concentrations limit enzyme turnover because the PHDs have a low affinity to oxygen as compared to collagen hydroxylases for example.
Unfortunately, marked mismatches between CGMS readings and actual blood glucose (BG) concentrations limit the usefulness of CGMS in preventing hypoglycemia (1).
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However, the fermentation cost on high glucose concentrations limits their use for biodiesel production.
At low temperatures/Au concentrations, limited spreading was accompanied by nearly complete isothermal solidification.
However, these radiotracers are high-affinity P-gp substrates and consequently display very low brain concentrations, limiting their suitability as PET tracers [5, 7, 8].
Recently, a GPER antagonist showed at high concentrations limited binding properties and stimulatory activity on ER-mediated transcription [ 30].
The low signal/noise of both the Se and As spectra (resulting from their low concentrations) limits more detailed comparisons with published results.
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CEO of Professional Science Editing for Scientists @ prosciediting.com