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Our analyses of PM RyR2 have concentrated on RINm5F insulinoma cells (185), where 4-chloro m-cresol (4CmC), at concentrations likely to be selective for activation of RyR1 and RyR2, evokes both Ca2+ release and Ca2+ entry, the latter via a pathway that appears not to involve SOCE.
MICs/MBCs were significantly lower than concentrations likely to be achieved in topical clinical use.
We directly compared D- and L-forms of the same amino acid, and the D- and L-forms of their corresponding tripeptides, to test the hypothesis that non-symbiotic higher plants are able to take up and assimilate amino acids and small peptides supplied at the low concentrations likely to be present in soil solution, irrespective of entantiomeric form.
In the early clinical development program for caspofungin, a target concentration of 1 μg/mL was used as a guide for concentrations likely to be efficacious.
Human PXR has very broad specificity for steroid hormones and their synthetic intermediates albeit mostly at micromolar concentrations likely to exceed typical physiologic concentrations [ 2, 8].
Therefore, in considering whether drugs are present in the environment at concentrations likely to cause effects, the total load of a particular class of drugs must be considered.
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Electrolyte changes during exercise also tend to exert many effects on neuromuscular excitability, with the extracellular potassium concentration likely to play a dominant role.
He then added Roundup to the water to achieve a concentration of 3.8 mg/L, the highest concentration likely to be found in nature.Within a day, Roundup completely eliminated leopard frog and grey tree frog tadpoles and nearly exterminated the wood frog tadpoles.
Odorant concentration had a positive effect, with odorants at high concentration likely to become key odorants.
Sterile roots of wheat (Triticum aestivum L). plants were exposed to solutions containing either 14C-labelled L-alanine, D-alanine, L-trialanine or D-trialanine at a concentration likely to be found in soil solution (10 µM).
Measurements in live, unprocessed specimens are clearly preferable for estimates of concentration likely to be affected by sample processing procedures that may alter cell volumes differently in cells with normal and altered permeabilities.
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