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Therapeutic drug monitoring is commonly carried out using plasma drug concentrations (free plus protein bound drug).
Moreover, if present in high concentrations, free FAs will lead to lipotoxicity and ultimately to cell death.
EGP is primarily regulated by portal insulin concentrations, portal glucagon concentrations, ambient glucose concentrations, free fatty acids, the autonomic nervous system, the hypothalamus, and cortisol.
At high concentrations, free radicals can cause damage to various cell structures, comprising proteins and nucleic acids, together with lipid peroxidation [ 2, 3].
Testosterone concentrations (free and conjugated testosterone) in the blood serum were consistent with previously reported levels in SV-40 Tag rats [ 28- 30], whereas DHT and estradiol concentrations in SV-40 Tag rats have yet to be published.
RR determined by the ZNF method was obtained solely by MD, i.e. reflecting the free fractions of MMC, while in the flow rate experiments, RR was calculated by equation (2), where the dialysate concentrations were divided by total plasma concentrations (free and protein-bound).
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Although it may be argued that serum concentrations do not resemble nasopharynx concentrations, free-drug concentrations were used as an approximation despite the fact that protein binding of the highly bound cephalosporin may not highly influence bacterial killing [38].
The uniform shear leads to a special symmetrical distribution of mean concentration free of skewness.
Indeed, the total plasma concentration (free carnitine + acylcarnitine) is only 45 85 μmol/l.
We observed a significant association between serum testosterone concentration, free testosterone concentration, and the severity of ED in the group with arsenic exposure < 50 ppb (Table 2).
Different studies, for example, have concluded that reducing sugar concentration, free asparagine concentration or free asparagine concentration as a proportion of the total free amino acid pool could be the determining factors (Amrein et al. 2003, 2004; Becalski et al. 2004; Elmore et al. 2007, 2010).
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