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Several improvements have tried to remove these limitations, including the Power-law approximation (S-system) [ 5], the (Log)Linear refinement of the MCA model [ 6] and lin-log kinetics [ 7] which have been developed to consider enzyme concentrations, feedback regulators and reversible enzyme reactions in the models.
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Regulation could also be linked to LH concentration feedback mechanisms as the absence of LH caused cultured TC to markedly up-regulate amounts of LHR mRNA.
Thus, high CA levels inhibit TH activity and thereby regulate its own intracellular concentrations via feedback regulation.
Additionally, concentration levels are not present in the flux model and so concentration-based feedback loops are not considered.
Signal amplification by restricted diffusion would require PI concentration-dependent feedback amplification.
Although we could not establish a single theoretical explanation, accounting for this observation when using the first measured concentration as feedback for dose revision was important.
It is reasonable to assume that the intervention, for which concentration and feedback was of key importance, was mentally challenging and thus "draining" in comparison to the relatively relaxing placebo intervention, which required no concentration.
While preliminary, this mechanism could direct macrophages to the tumor edge where they further amplify CSF-1 concentrations through positive feedback mechanisms as discussed above.
In another type of carbon cycle-related study, Zickfeld et al. ([2011]) examined the nonlinearity of climate- and concentration-carbon cycle feedback using UVic-ESM.
This analysis shows a relation between the patterns of water temperature and of DO concentrations with important feedbacks on the life and metabolism of aquatic organisms; as well as on the reaction rates, which control the biogeochemical processes within the streambed sediment.
The effects of protein concentration profiles by feedback control on GAL1 mRNA expression on the GAL network are illustrated in Figure 7.
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