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High plasma morphine concentrations failed to significantly change cold pressor and electrical stimulation pain tolerance for methadone patients, but in controls, morphine significantly (P < 0.05) increased mean pain tolerance to cold pressor by 59±29%9% (range −17%too 311%) and electrical stimulation by 19 ± 6% (range 0%to58%8%).
Insulin alone at increasing concentrations failed to alter the LPS-stimulated IL-6 production.
Reduced glucose concentrations failed to completely suppress insulin secretion in islets from RIPCreα 2KO and α 1KORIPCreα 2KO mice, and conversely GSIS was impaired.
While QN treatment increased the amount of LC3 puncta at nearly all concentrations, the same CQ concentrations failed to achieve an appreciable increase in puncta number (Fig. 2A).
Similarly, addition of MBP at any of these concentrations failed to attenuate the increased testosterone production induced by addition of 22R-CHO.
On the contrary, treatments with rosiglitazone or ciglitazone at 50 μ M concentrations failed to affect the phosphorylation or expression of Stat3.
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However, ambient concentrations fail to account for additional exposures from indoor sources.
In contrast, even infusions that achieve supraphysiological GIP concentrations fail to elicit a significant insulin secretory response in patients with type 2 diabetes (5).
Several studies have demonstrated unfavourable pregnancy outcomes associated with high Hgb concentrations early in pregnancy, as well as in situations where Hgb concentrations fail to decline in the mid-trimester [ 40].
Cooking area pollution concentrations can provide a quantified measure of the environment (Table 1, method C); however, these area concentrations fail to capture personal exposure measures because of large spatial heterogeneity and differences in time activity patterns.
To understand why FGF-2 at high concentrations fails to stimulate DNA synthesis, two important signalling events downstream of the FGFR were examined, the phosphorylation of the adaptor FRS2 and of p42/44 MAPK.
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