This response was significantly enhanced by co-treatment with TNF-α at a concentration devoid of any secretory effect per se (10 ng ml−1).
On the other side, selective non-vasoconstrictive 5-HT1F receptor agonists, LY334370 [42] and LY573144 (i.e. lasmiditan) [43] demonstrated clinical efficacy, even though it remains to be confirmed whether these molecules, at therapeutic concentrations, are devoid of any activity on 5-HT1B receptors.
As shown in Figure 3, treatment of MDA-MB-231 cells with GGTI-298 caused a significant decrease of cell invasion, while FTI-277, an inhibitor of FTase, at the same concentrations, was devoid of effect.
Moreover, the Ki of LCA towards EphA2-ephrinA1 interaction was six times lower than its critical micelle concentration [24], LCA was devoid of any toxicity at the studied concentrations and both binding and functional tests reported the same range of LCA activity included between 20 to 100 µM.
Control cultures were treated with neurobasal medium containing identical DMSO concentrations as above but devoid of 4-AP, bicuculline and inhibitors.
Hence it cannot be produced by an empty and dull mind; hence those artists who embrace the creed of pure art or art for art's sake, and close their hearts to the troubles of life and the cares of thought, are found to be wholly unproductive, or at most rise to the imitation of others or to an impressionism devoid of concentration.
At this concentration, L012 is reportedly devoid of redox cycling properties (Sohn et al., 1999).
We assume that: ● For a given pollutant its "true" background concentration (i.e. devoid of bias or measurement error) in grid-square i on day t of a 3-year time-series is: x i, t * i = 1, …, 100 ; t = 1, …, 1095 ● For each grid i, the "true" 3-year time-series, represented by the vector X i *, exhibits no trend or seasonal variation.
Indeed, fractionation studies suggest that mitochondria are devoid of significant concentrations of Fbxo15 under native conditions or after ectopic expression of Fbxo15.
The anodic and cathodic polarization curves of carbon steel (X52) in 1 M HCl solution devoid and containing increasing concentrations of SSE are shown in Fig. 6.
