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Foliar application of SA, SNP or 1/2 SA+SNP), particularly SA+SNP showed a positive influence on Fe concentrations, active Fe content, and FCR activity.
The administration of suboptimal chemotherapeutic concentrations, active only for planktonic forms, not the main infection factor, may be inefficient for pharmacological therapy.
Clinical studies have shown dose-limiting toxicity of hypotension and heart block when plasma levels approach the concentrations active in vitro.
It should be noted that the concentration of mexiletine found to be effective in the experiments described is much higher than expected, based on the therapeutic concentrations active clinically.
The NRC report discussed tools for interpreting in vitro results for risk assessment - i.e. computational systems biology models of pathways and pharmacokinetic models to equate concentrations active in vitro with exposure expected to lead to these concentrations in human populations.
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Such enzyme also may have critical endogenous roles such as regulation of ion concentration, active transport or mitochondrial metabolism.
Therefore, it is not the intracellular topotecan concentration (active plus inactive drug) per se that determines the targeting of the enzyme and the levels of cleavable complex formation.
Furthermore, systemic and coronary artery concentrations of active GLP-1 might differ due to myocardial DPP-4 activity.
Mass transport can then control concentrations at active sites and thus product compositions.
(2) The concentrations of active forms of MMP-2 and MMP-9 changed with advancing gestational age.
Of these, 21% (9/42) had zero or very low concentrations of active ingredients.
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