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The net result depends on both the antibiotic concentrations achieved and the susceptibility of bacterial species in the microbiota.
Concentrations achieved in vivo in tumors lead to single-agent anti-tumor activity at non-toxic doses.
Ketamine, at concentrations achieved with standard clinical doses, has a direct relaxant effect on airway smooth muscle.
CC-930 was rapidly absorbed following oral administration, with mean peak plasma drug concentrations achieved by approximately 1 h (Additional file 1: Figure S7).
We will discuss the relevance of pharmacological data as a function of doses or concentrations required for a given effect and of concentrations achieved in the target tissues.
Therefore, at concentrations achieved with therapeutic dosages, two steps in folate metabolism within bacteria are blocked, while human metabolism is unaffected.
The laminin-10 concentration in the conditioned medium exceeded 10 mg/l, which is 10-fold higher than the concentrations achieved by conventional recombinant expression systems.
However, drug concentrations achieved in receiver compartments were comparable to those required to induce high levels of cell death upon irradiation in cell lines reported in the literature.
Considering that decrement times depend on the concentrations achieved as well as the dose history, it is often difficult for clinicians to anticipate a patient's time to recovery.
To measure the plasma fentanyl concentrations achieved over time with transdermal fentanyl patches in awake cats and cats undergoing anesthesia and ovariohysterectomy.
The plasma concentrations achieved were consistent with the prediction based on the First-Time-In-Human safety and tolerability study (GSK study number 110623 and study number NCT00743405 on CT.gov).
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