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They obviously should be confirmed by additional experiments and alternative methods to understand the kinetic and the carbon source concentration-dependent regulations.
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Another study notes a concentration-dependent regulation of Gremlin expression in that low concentrations of BMP2 upregulate Gremlin while high concentrations of BMP2 downregulate Gremlin in limb mesenchyme cultures51.
Importantly, the binding of serine arginine proteins such as SRRM2 to their degenerate recognition exonic sequences is intrinsically weak, resulting in a concentration-dependent regulation, for example, certain sequence elements are recognized only at higher SR protein concentration[36].
In Arabidopsis, expression of four PLT genes (members of the AP2 sub-family) in overlapping as well as specific regions of the root allows for PLT concentration-dependent regulation of root growth and development [ 32].
Interestingly, 28 proteins significantly reacted at very low concentrations (<LC01) and showed an exposure concentration dependent regulation status.
Next, we ask generally which regulators are able to specify eve expression (regulator discovery) and consider the plausibility of concentration-dependent dual regulation.
As shown in Fig. 6, both masked and non-masked LPS induced concentration-dependent up-regulation of CD40, CD80 and CD83, whereas CD86 expression was partially reduced.
Concentration-dependent down-regulation of GalR1 protein expression in human melanoma cell line Bowes was measured by radioligand binding assay.
(B) PMA concentration-dependent down-regulation of P-Rex1 protein expression in MCF-7 and BT-474 cells.
A concentration-dependent up-regulation of the gene was observed on treatment with ATRA (Table 1).
Using these conditions, we identified a concentration-dependent up-regulation of iNOS expression following both monomeric and aggregated forms of α-synuclein.
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