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Our studies show that reduction of VE-cadherin expression does not change vascular patterning but leads to a concentration-dependent alteration in vascular integrity and lumen formation.
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These concentration-dependent alterations include changes in surface characteristics, cellular shape, and alignment.
Because of the fact that Akt upregulates ABCB1 (Garcia et al, 2009), further studies should determine whether the concentration-dependent alterations in ABCB1 expression by HIV-PIs are Akt dependent.
Both genotype-dependent and concentration-dependent ultrastructural alterations were observed in root tip cells of the experimental cultivars– 2(f)).
Concentration-dependent functional alterations of isolated platelets were analyzed by flow cytometry, assessing changes in surface P-selectin expression and platelet-derived microparticles before and after in vitro stimulation with norepinephrine ranging from 10 nM to 100 μM.
The microarray analysis revealed several concentration-dependent gene expression alterations including classical estrogen sensitive biomarker gene expression (e.g. estrogen receptor α, vitellogenin, zona radiata).
The glucose concentration could alter the expression of GDNF and RET in a concentration-dependent manner correspondingly with an alteration in cell proliferation.
Alterations in gene expression followed four distinct concentration-dependent patterns: (1) concentration response (e.g. estrogen receptor alpha), (2) inverse-concentration response (e.g. insulin receptor beta), U-shaped (e.g. mineralocorticoid receptor), (3) inverse U-shaped (e.g. benzodiazepine receptor), and (4) concentration-independent responses (e.g. ubiquitin).
Further, oxygen induces S-phase growth arrest and increases p53 and p21WAF1/CIP1 expression in human bronchial smooth-muscle cells leading to oxygen-mediated alterations in proliferation are time- and concentration-dependent manner.
In our study, acute exposure to atrazine resulted in significant concentration-dependent changes in almost all haematological and biochemical indices and in the case of some indices these alterations were irreversible after 7-day depuration in atrazine-free water.
AMP cytotoxicity is concentration-dependent.
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