Plasma concentrations were quantifiable in all patients through 72 h.
Plasma concentrations were quantifiable in all patients through 48 72 h (Table 5 >).
Table 3 summarizes the pharmacokinetic results for those subjects from which SMT19969 concentrations were quantifiable and could therefore be included in calculation of PK parameters.
Eight compounds— p,p′-DDE, β-HCH, HCB, α -endosulfan, oxychlordane, p,p′-DDT, dieldrin, and cis-HE (listed with decreasing concentrations)—were quantifiable in all samples.
After oral prednisolone administration to cats, we observed that plasma and aqueous humor concentrations were quantifiable at 0.25 h, demonstrating that both prednisolone absorption and aqueous humor distribution processes were fast.
Pharmacokinetic parameters were only calculated from the groups dosed under fed conditions (Part 1 1,000 mg, Part 2 200 mg BID and 500 mg BID), as SMT19969 concentrations were quantifiable in one or more sample from the majority of subjects in these groups only.
Only an IgG band was quantifiable (estimated serum concentration from the protein electrophoretic pattern, ≃1 g/l); all others had trace quantities (<1 g/l estimated concentration from protein electrophoresis) (Table 2).
The LOQ corresponds to the lowest concentration that is quantifiable given accuracy criteria of < ±15% and a signal-to-noise ratio >10 AU.
In an experimental sheep model, no colistin was quantifiable in the ELF after intravenous infusion of CMS, whereas high ELF colistin concentrations were measured after nebulization [39].
We were unable to reproducibly measure glutathione concentrations in microsomal fractions of cultured cells; however, the effect of ChaC1 over-expression on total cellular glutathione was quantifiable.
