Restaurants require concentration and timing.
The disease or functional outcome will depend on the stressor, its concentration and timing.
Intriguingly, however, the incubation of ES cells with H2O2 either enhances or impairs the cardiomyogenic program, dependent upon the concentration and timing during differentiation suggesting both a dose-dependency and a cellular competency in the response to ROS [63,92,96].
This game requires a lot of concentration and timing to play correctly and you don't want to keep trying if you are getting frustrated.
Santiago Ropero (Hospital 12 de Octubre, Madrid, Spain) showed, however, that combination treatment of breast cancer cells with herceptin and tamoxifen could be additive, synergistic, or antagonistic for cell growth, depending on concentrations and timing.
Moreover, the apparent temporal activity of IAA/ARF modules may instead be driven in planta by changes in auxin concentrations rather by timing as proposed [6].
By testing out the optimal concentration and timing of adding FGF4 and RA, we show for the first time that RA and FGF4 in a dose-dependent manner synergistically induce differentiation into PDX1+ cells (on average 32%).
"The key is focus, concentration and timing," Froemming said.
The former is due to the concentration and timing of the large slip occurrence (i.e. earthquake slip for the kinematic case is more spread out), whereas the latter represents the combined effects due to the tsunami source and propagation.
