Concentration-responsive effects of roxarsone and AsIII on the angiogenic potential of HAEC and HMVEC were compared in quantitative high-content cellular imaging tube-formation assays in Matrigel.
This is demonstrated by a clear concentration-responsive effect, and a distinct effective concentration of 0.2 μg E2 L−1, as shown by the frequency of female/male individuals and the occurrence of substantial mixed sex and other abnormalities.
COX-2 protein was upregulated by irradiation in a time-responsive manner, but it was downregulated by EPA in a concentration-responsive and time-responsive manner (data not shown).
Concentration-responsive effects of roxarsone and AsIII on the angiogenic potential of HAEC and HMVEC were compared in quantitative high-content cellular imaging tube-formation assays in Matrigel (BD Biosciences, San Jose, CA, USA).
Quantitatively, extrapolation across species can be illustrated by applying pathway-based benchmark concentration modeling in combination with the human reverse toxicokinetic modeling of Wetmore et al. (2012) to the flusilazole concentration-responsive retinol metabolism pathway of zebrafish embryos, described above.
(D ) Quantification of the percent of high concentration BZ responsive neurons.
When detecting Cu2+ solutions with different concentrations, the responsive currents were similar but the relative conductance changes were different.
The EXiLE scores 1, 2, 3, and 4 correspond to the minimum concentrations of responsive EWP; 1000, 100, 10, and 1 ng/ml, respectively, while 0 means a nonresponder.
Statistical significance compared with control: ***, P < 0.005; **, P < 0.01; *, P <0.05; compared with 20 μM NOM: † P <0.05; compared with responsive concentration of NOM, ‡ P <0.05.
When detecting Cu2+ solutions with different concentrations, the dynamic responsive current of the MEGS-based electrical circuit was also similar to that of detecting DI water.
