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The concentration response relation was linear (R = 0.9992) within this range.
Four other doxepin concentrations (30, 100, 300μM and 1 mM) were also tested in order to construct a concentration response relation for inhibition of Y652A IHERG tails (Fig. 7B).
Our first analysis fit a Cox proportional hazards model, as described above, but used a penalized spline to estimate the concentration response relation between annual PM2.5, as a time-varying covariate (the concentration in each year of follow-up), and mortality experience in the Six Cities cohort.
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It depends on sample size as well as on concentration-response relation.
The ECxx calculation relies on a parametric assumption about the concentration-response relation (concentration-response curve) underlying the data.
The major criticism regarding the ECxx concept is the need of specifying a mathematical model for the concentration-response relation.
The terms a and b in this equation control location and scale (slope) of the concentration-response relation.
The full information about the relation between concentration and toxicity (effect) is described by the concentration-response relation (see example in Fig. 1a).
Given an initial assumption, we propose the following concentration allocation strategy: calculate EC10, EC50, EC90 from the planning assumptions, assuming a logistic concentration-response relation and involving SL and IY, if the selected risk type requires so.
The effect of ANP was not voltage-dependent, since ANP induced propotional reduction of peak ICaL at all potentials tested (Fig. 3B). Figure S1 shows concentration-response relation between ANP and the ICaL.
The current amplitude decreased in agreement with the concentration-response relation shown in Figure 2A.
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