This inevitable sampling-bias currently constrains inferences about causal neurotransmitter function relationships, but advances in multivoxel MRS 180 (particularly at higher field strengths) are likely to provide increasingly detailed mappings of stimulation-evoked changes in neurotransmitter concentration with relevance for cognition.
With increasing concentrations, the relevance of competition for the characteristics of the concentration response relationship decreases, and the sole effect of the pesticide dominates.
At dissolved CO2 concentrations of relevance to field conditions (15 180 μM; e.g. in Thailand, Setter et al. 1987; India, Ram et al. 1999), underwater PN was enhanced 4- to 4.9-fold by gas films on leaves of rice (Pedersen et al. 2009).
In addition, our results have shown a lack of correlation between mRNA levels and functional protein concentrations, questioning the relevance of measuring mRNA concentrations.
Retrospectively, Wang et al. (Wang et al., 2009) reported the pilot exploration of fatty acid metabolism in Shewanella piezotolerans with concentration on its relevance to different temperatures and pressures.
Thus, Pb in the concentration range of relevance for its biomonitoring can be accurately quantified.
Furthermore, it is possible that miRNA mimic transfection achieves cellular concentrations beyond physiological relevance.
However, because we did not evaluate the within-individual changes in Lp-PLA1 concentrations, the clinical relevance of our observations remains uncertain.
The authors concluded that although a number of behavioral end points were affected at relatively high concentrations beyond environmental relevance, it would be unrealistic to attribute the effects to an endocrine-mediated process.
The micromolar concentrations of Aβ species used in this study were approximately six orders of magnitude greater than in vivo Aβ concentrations, and the relevance of cell culture MTT-type assays to the in vivo synaptotoxicity of Aβ species has been questioned [ 134].
