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Increase in nutrient concentration, primarily PO4 2− and NO3 −, enhanced biological metabolism thereby decreasing dissolved oxygen (Hickman and Gray 2010; Nyamangara et al. 2013).
Nitrate removal is also limited by the rate of C supply from degrading substrate and removal is operationally zero-order with respect to NO3− concentration primarily because the inputs of NO3− into studied bioreactors have been generally high.
These can overwhelm the normal defences that should protect against a significant fall in plasma glucose concentration, primarily by preventing a compensatory fall in circulating insulin.
Specifically, coadministration of paroxetine, an SSRI, was associated with a significant decrease in plasma endoxifen concentration, primarily in patients with the EM phenotype (by 58 72 %) [ 9, 13, 14].
However, during fast metabolic transitions involving significant changes in the pyruvate concentration, primarily resulting from major changes in glycolytic rate, the LDH isoenzyme pattern may well play an important role in the compounded metabolic response to altered energy metabolism.
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We have shown previously that DmmtSSB can stimulate ∼20-fold in vitro DNA synthesis by Dmpol γ over a broad range of KCl concentrations, primarily by enhancing primer recognition and binding [8], [19].
The HOMA-IR index derived from the product of fasting glucose and insulin concentrations primarily reflects hepatic insulin resistance.
The BD photochemical product concentrations, primarily acrolein, within the chamber during the exposure were also very similar (within 0.020 ppm).
Thus, the predicted exposure concentrations primarily reflect the balance between emissions inventories of fresh particles and meteorological fields that drive dispersion and chemical reaction.
It is, therefore, possible that high suPAR concentrations primarily reflect endothelial dysfunction that is a key driver in sepsis morbidity and mortality [ 27].
In the case of the leverage plots from the multiple regressions, the considerable variability in the health parameters relates to blood Hg concentrations primarily at the extreme ranges.
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