A TfR-lytic hybrid peptide concentration of merely 15-20 μM was sufficient to induce more than 80% cell death in all cancer cell lines examined.
Our results seem to agree with those of an earlier study, where the increase in ABA concentration was merely coincident with ethylene evolution during ripening in 'Jingbaili' and 'Gold Nijisseiki', Asian pears [ 89].
Note that the agreement covers GHG concentrations, not merely emissions.
The data of the eighth concentrations thus merely represented a safety feature and were not used for further analysis.
It has been suggested that tumor ascorbate concentrations may merely reflect the abnormal tumor physiology (hypoxia or necrosis due to poor vascular supply).
In order to test whether the changes in sodium and chloride concentrations were merely related to changes in salivary flow rates, the patients and healthy controls were matched by their UPS and SPS flow rates within the range of 0.01 1.00 ml/min.
Since imatinib alone has little or no measurable effect and does not potentiate the effects of established cytotoxic treatment in BCR ABL-negative cells at therapeutically relevant concentrations, even merely additively acting imatiniBCR ABL-negativebinations as shown in cellsells should exert more selective toxicity on the leukatmic cell clone as compared witherapeutically- orelevantherapy alone.
We stress again the observation that with increased fusion, ATP concentration, rather than merely the rate of production and consumption of ATP, changes.
Would not a more straightforward explanation be that glutamine is transported downhill following a concentration gradient resulting merely from decreased plasma glutamine during sepsis, reflecting a change in pool size of cerebral glutamine?
Increasing the dose of the artemisinin component in ACT might partly overcome decreased sensitivity, in case the concentration-effect relationship has merely shifted to higher concentrations in this parasite population.
However, the argument we wished to make in our paper was a general one: that considering merely the concentration of the prodrug (C in our model) could be misleading, since the concentration profile of the active drug (A) in the tissue could be very different.
