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In addition, both Dystrophin and Coracle were required for normal Dg concentration at the synapse.
An increased extracellular glutamate concentration at the synapse level has been implicated in hippocampal cell death.
This is relevant as zinc, which is co-released in high concentration at the synapse during activity (Frederickson et al., 2006) together with glutamate, plays a crucial role in learning and memory via its function as a neuronal messenger and a modulator of synaptic transmission and plasticity (Smart et al., 2004; Paoletti et al., 2009).
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The SSRIs act by blocking 5-HT reuptake, thus increasing the concentration of 5-HT athehe synapse, enhancing the serotonergic neuronal transmission.
Although we do not know the local concentration of muscarine or ACPA at the synapse, the concentrations used produced changes similar to bath application of either chemical.
SSRIs block serotonin re-uptake, boosting its concentration in the synapse.
This in turn causes high dopamine concentrations in the synapse and thus longer lasting effects [ 12].
CaMKII is activated when the arrival of a nerve impulse at the synapse causes an increase in the concentration of calcium ions within the cell.
Since synaptic loss is one of the first pathological hallmarks of AD [25] and high local concentration of Aβ could induce this degeneration, we were interested in whether active γ-secretase was present at the synapse.
(For further discussion, see below Transmission at the synapse).
These properties include not only which other neuron classes the synapses come from, but whether they are excitatory or inhibitory, the nature of the learning rule implemented at the synapse, and the initial strength of such synapses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com