According to safety aspects we documented severe bleedings in the event of short term decline of hemoglobin level (≥ 2 g/dl/48 h) in absence of other evidence (e.g. hemolysis) and/or the need for at least two red blood cell concentrates in case of confirmed blood loss and/or the clinical occurrence of serious apparent bleeding in parenchyma, muscle or cerebrum.
As shown in Figure S2, the variation patterns of isomiR sequences are quite diverse with the variations primarily concentrated in 3' positions (32 cases, Figure S2A) as opposed to the 5' position (four cases, Figure S2B), but variations may also occur at both 5' and 3' positions (four cases, Figure S2C).
In that study, cases were concentrated in southwestern states; four cases were found in Oregon during a 2-year period (8 ).
In consequence, in Candelária, in 2005, 97 vivax malaria cases concentrated in only 40 houses, while 48 houses were negative for malaria cases and in 2006, 79 vivax malaria cases occurred in only 39 houses, while 41 cases had no malaria cases The average number of vivax malaria episodes per positive household was 2.78 in 2005, and 2.32 in 2006.
A substantial number of probable SARS cases were concentrated in Asian countries during the previous SARS epidemic (5,327 cases in China, 1,755 cases in Hong Kong, 346 cases in Taiwan, and 238 cases in Singapore as of July 31 , 2003 (1).
Those cases had been heavily concentrated in the Americas, but the rise in cases in Australia and elsewhere indicate communitywide spread in other world regions.
The majority of cases are concentrated in the second time period from 2000 2006 (151 cases out of 198, or 76.3%).
Opinion pollsters have been hampered by the impact of Sandy, both in contacting voters in swing states directly affected and because their own call centres – concentrated in New Jersey in several cases – have been compromised by the storm.
In recent years, an illegally manufactured version of the drug has begun spreading, with cases concentrated in the eastern half of the United States.
An estimated 5 10% of CRS patients requiring surgery have AFRS, although a distinct geographic variation exists with cases concentrated in warm, humid climates such as the southeastern United States and India.
