The use of serum might decrease the above mentioned confounding variables, possibly allowing the detection of a more concentrated disease-related miRNome by decreasing blood cell-related background expression of miRNAs through co-morbidities, for example.
Similarly, the accumulation of human-specific and human-concentrated phenotypes along our lineage (e.g. Harris and Meyer 2006; Crespi 2010a) generates novel mutational targets for human-specific and human-concentrated disease.
In principle, human-specific derived alleles should underly some proportion of human-specific or human-concentrated disease risk (Crespi 2010a), with ancestral alleles, losses of function, or pleiotropic effects of derived alleles, associated with higher risk of disease.
A key benefit from bridging between human medical genomics and human evolutionary genomics is reciprocal illumination of answers to two of the major unresolved questions in biology: how we evolved, and why we fall victim to cancer, schizophrenia, type 2 diabetes, and a suite of other polygenic, human-concentrated diseases.
To increase the probability of biomarker discovery, the closer in proximity one can get to the diseased tissue, the more concentrated will be disease specific proteins, peptides, nucleic acids, and metabolites.
The results highlighted concentrated pockets of invasive disease in the Jewish orthodox community (annual incidence 16/100,000).
Tuberculosis incidence rates in excess of 60/100,000 in parts of metropolitan Sydney represent concentrated pockets of imported disease, which may support local transmission [ 6].The NSW Mycobacterial Reference Laboratory (MRL) provides ongoing laboratory surveillance to help identify local tuberculosis outbreaks and guide public health responses.
"I think we would need a much bigger and concentrated effort to define proper disease subtypes of chronic and diabetic kidney disease.
We are also working on something similar in the nephrology field, but I think we would need a much bigger and concentrated effort to define proper disease subtypes of chronic and diabetic kidney disease.
The emphasis is no longer on the disposition of diseased bodies in space but rather on areas where disease is highly concentrated and where the risk of transmission is intensified (Huxley 2006).
If one variety of a crop is susceptible to a disease, the more concentrated those susceptible types are, the more easily disease can spread and the more victims it can claim.
