Sentence examples for concentrated design from inspiring English sources

For these hypothetical test cases, the relative advantage between distributed and concentrated design was more nuanced that the previous cases.

The results of this design are more complex to analyze than for the concentrated design, requiring a model of the D R relationship.

In contrast, if a safety signal was detected by a concentrated design, the sponsor would have no guidance on how lower doses may reduce the safety signal.

An advantage to the concentrated design is evident in the percentage of correct No-Go decisions for these hypothetical test cases (Table 3 ), and the advantage was 3 6%.

One typical FIP study design may be to assign the patient either placebo or the highest tolerated dose in healthy volunteers (hereafter: concentrated designs).

Our instincts, examined under the conditions in this paper, are not supported: concentrated designs are not substantially better for demonstrating a drug "works" than distributed designs in this context.

Figure 2 shows that the median of the estimates of absolute improvement over placebo deviated from the true value for the concentrated designs more so than for the distributed designs.

For lowpomab and nopomab cases, distributed designs at the 7 1 active:placebo ratio were better by 2%, at the 3 1 active ratio equal to the concentrated designs, and at the 5 3 and 1 1 active:placebo ratios worse by 2 7%.

We have evaluated concentrated designs (subjects dosed placebo or 700 mg intravenous) and distributed designs (subjects dosed placebo or 21, 70, 210, or 700 mg) for small simulated FIP (N = 16) studies in psoriasis.

The concentrated trial design involves assigning all psoriasis patients either placebo or the highest feasible drug dose level tested in healthy volunteers (700 mg).

These products are concentrated and designed to deep clean without damaging the stone.