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Solid feed during period 2 consisted of maize silage and barley straw (50 50 ratio on DM basis) for the nonconcentrate groups, and maize silage, barley straw and concentrates (25:25:50 on a DM basis) for the concentrate groups.
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Bleeding and transfusion of allogeneic blood products were lower in the fibrinogen concentrate group.
One group was fed a control diet comprising 65% forage and 35% mixed concentrate (low concentrate group, LC), while the other group received a high-grain diet containing 65% mixed concentrate and 35% forage (high concentrate group, HC).
The mean bleeding mass was significantly lower in the fibrinogen concentrate group than in the cryoprecipitate group after 30 minutes.
In the fibrinogen concentrate group, some subjects received fibrinogen concentrate as a sole source of fibrinogen, while others received fibrinogen concentrate and allogeneic blood products.
In all studies, plasma fibrinogen levels were significantly higher postadministration in the fibrinogen concentrate group than in the control group (which received FFP in two studies).
Total avoidance of allogeneic blood product transfusion was achieved in 70% of patients in the fibrinogen concentrate group versus 18.2% in the cryoprecipitate group (P < 0.001).
Importantly, plasma fibrinogen levels were not significantly higher in the fibrinogen concentrate group than in the control group at the next assessment point (6 to 24 hours later).
The thorax was opened after study medication in zero patients (0%) in the fibrinogen concentrate group and in six patients (18.2%) in the cryoprecipitate group (P = 0.025).
One observed a significantly reduced hospital LOS for patients in the fibrinogen concentrate group compared with the control group (21 days versus 32 days, respectively) [ 56].
The placebo group received allogeneic blood products, including fresh-frozen plasma (FFP; n=32); the fibrinogen concentrate group received fibrinogen concentrate alone (FC; n=14), or fibrinogen concentrate followed by allogeneic blood products (FC+FFP; n=15).
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