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Children conceived with the use of assisted reproductive technologies (ART) appear to have an increased incidence of BWS.
- About 50% of naturally occurring BWS cases present with loss of methylation at KvDMR1 on the maternal allele, which is coupled with biallelic expression of KCNQ1OT1 and downregulation of CDKN1C., Reports estimated a 3- to 9- fold increased likelihood of BWS in children conceived with the use of assisted reproductive technologies (ART).
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