Because NA is determined by considering both the thickness and elastic modulus of a buffer layer, the design rule is conceived to be applicable regardless of the material and thickness that are used for the buffer layer.
While the classical "structure-based design" paradigm is still mostly conceived to be applicable in later lead optimization phases, the greatest impact will in fact be generated in the early project phases, hit finding, and validation.
Illustrated with the bacteriophage Qβ in Escherichia coli, this strategy was conceived as a broadly applicable approach to engineer resistance against pathogens.
Even though by extension it is often referred to as "ligand efficiency", the concept was originally conceived to be strictly applicable to comparing the binding efficiencies of ligands for a single target.
*: not WRLFMD reference numbers -: host animal not indicated NA: not applicable CA conceived and designed the study, undertook field work, laboratory studies, data analysis, manuscript preparation, review, corrections and submission.
Womack et al. (1990) were the first to conceive lean production as a configuration and have summarized it as a universally applicable system.
Keller said that he was "not a lawyer," but that it would be "hard to conceive of a prosecution of Julian Assange that wouldn't stretch the law to be applicable to us.
The honor of Muslims is Palestinians like Yasser Abd Rabbo and others, many others, who, a little over a decade ago at Geneva, joined forces with Israelis to conceive and present the only plan for peace to this day which is serious, viable and immediately applicable, as it rests on the precondition of simultaneous mutual recognition.
Therefore, if embryo quality is shown to improve with the dietary intervention, it is more applicable to the general population and is likely to be of benefit to all trying to conceive and to their offspring.
How anachronistic it will soon seem to conceive a big creative idea without thinking about how to turn it into a media event, make it viral and applicable across media, allow consumers to mash it up and remould it.
