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Note that the run-time calculation excludes the alignment procedure, but includes all other computations (including computing alignment probabilities in BitSeq's case).
Geometric and chemical similarity of matched NCIVs should be taken into account when computing alignment scores.
We chose Smith and Waterman local alignment algorithm for computing alignment score.
All of these algorithms used the EMBOSS implementation of the Smith and Waterman local alignment algorithm for computing alignment score.
In addition, an intraspecies alignment tends to be less accurate than an interspecies one, due to the difficulty of computing alignment scores corresponding to the actual divergence time [ 52].
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We used CyNetwork and CyNetworkView objects for network alignment visualization and custom classes for computing alignments.
Note that we also considered the possibility of designing a Bayesian scoring function, analogous to approaches used in computing alignments between optical maps (Anantharaman et al., 1997).
The second contribution introduced here is a new multi-segment alignment method, called SCOW, that features the ability to calculate 'shorted' alignments, a correlation-based scoring function, and an efficient dynamic programming algorithm for computing alignments.
This raises the question of what is consistently aligned within each tissue group and how it relates to the computed alignment p-values?
Both software packages assessed used a semi-automatic linear (or rigid) registration algorithm to fuse PET and CT data together; therefore, computed alignment transformation between image modalities included, and were limited to, rotation, translation and scaling.
Our method computes alignment anchors progressively according to a guide tree computed as follows.
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