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Randomization will be conducted centrally using a computer generated procedure.
When the questionnaires and the written signed consent had been returned an assistant not involved in patient care randomly allocated the patient by a computer generated procedure with no blocking or stratification giving each participant equal probability to receive either continued usual care or the IM model of care.
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One of the basic goals in computational topology is to create computer generated procedures for obtaining representations of objects having the same shape at least in some acceptable approximate sense as a given geometric object.
A computer generated randomisation procedure was used by a statistician independent of the centres (Toulouse University).
Each study treatment was placed in a numbered container according to a computer generated randomisation procedure with a block size of four.
Subjects were randomly assigned to groups using a computer generated block randomization procedure.
Adequate allocation concealment was ensured using a centralised computer generated block randomisation procedure.
Subjects were randomly assigned to groups using a computer generated block randomization procedure to ensure a similar proportion of participants in each group.
Allocations have been computer generated using the ralloc procedure 14 in Stata V.12.0 (Stata Corporation, College Station, Texas, USA).
We randomised participants by using a computer generated two block randomisation procedure with stratification on severity of COPD (mild or moderate v severe airflow obstruction), 2 smoking status (current v former smoker), and frequency of exacerbations in the previous 24 months (<2 v ≥2 exacerbations).
Patients were randomized with a 1 1 allocation ratio using a simple randomization procedure (computer generated list of random numbers prepared by an independent person not involved in the study) to either the Intervention group (butyrate, n = 40) or the Placebo group (normal saline, n = 40).
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