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Bayesian inference using Markov Chain Monte Carlo (MCMC) provides an explicit framework for stochastic calibration of hydrogeologic models accounting for uncertainties; however, the MCMC sampling entails a large number of model calls, and could easily become computationally unwieldy if the high-fidelity hydrogeologic model simulation is time consuming.
We also wanted the nodes of this network to be biologically meaningful but representing neurons as individual nodes would have made our model computationally unwieldy.
However, rather than creating a computationally unwieldy set of 6000 lattices, clusters of genes that behave similarly within experimental error, when "valves" are turned on/off via mutation, are approximated using a single lattice.
Using modeling approaches, if cellular representations are too detailed, it quickly becomes computationally unwieldy to explore large network simulations.
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It's an unwieldy subject.
"Our algorithm is faster and computationally simpler," Allesina says.
And anything unwieldy tends to fall apart".
He crammed women into unwieldy padded costumes.
The unwieldy objects sometimes clog the works.
"It's this big, unwieldy thing".
All of this feels impractical and unwieldy.
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