Sentence examples for computational targets from inspiring English sources
Still, deployment of such useful environments can be challenging – the systems tend to be large, addressing a wide span of computational targets that currently includes CPU-clouds, grids and local clusters, each with a huge range of possible operating system software and middleware.
To test if the miRNA-correlated mRNA genes are direct miRNA targets, we downloaded the miRBase database and compared the computational targets of each miRNA with the miRNA negatively correlated mRNA probes.
By comparing the miRBase computational targets of each miRNA/mRNA pair with the miRNA/negatively correlated protein pair, 1345 unique miRNA/protein pairs were identified as direct miRNA targets (Table S2).
This program uses computational targets generated using miRanda, PITA, TargetScan, and mirSVR, and determines gene targets for a set of microRNAs taking into account the relative expression of each microRNA in a set of samples.
We found it difficult to assess the biological significance of the suite of differentially regulated miRNAs and their computational targets culled from the study of Zhang and Pan (2009); although these miRNAs could be associated with exposure to RDX, they do not seem related to disease.
Such caveats are responsible for the increased interest in novel computational target deconvolution strategies for drug discovery [11].
Applications of successful in silico target identification attempts are discussed in detail, which were based partly or in whole on computational target predictions in the first instance.
Computational target prediction combined with a comprehensive functional validation enabled the discovery of a set of twenty putative target genes for all productivity enhancing miR-30 family members.
We developed Chiminey under directions by quantum physicists and molecular biologists, to ease the steep learning curve in data management and software platforms, required for the complex computational target systems.
Using multiple computational target predicting algorithms together with the luciferase-based reporting platform, the interactions between HF-related microRNAs and the 3′ untranslated regions (3′UTRs) of neurohormone associated genes were examined and compared.
Currently, miRNA target identification is based primarily on computational target predication algorithms.
