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Pharmaceutical research, in contrast, is measured in years, fails more often than it succeeds, and requires hard-core credentials and in many cases expensive equipment, not just hard work.Moreover, the computational portion of the drug-discovery process typified as upstream, far from the patient, at the early-stage level, where profits are thinner is not the costly bit.
To summarize these advances, the experimental portion of the workflow of our novel method is detailed in Figure 1, while the computational portion of the workflow is shown in Figure 2. Generation of an Illumina library requires large amounts of dsDNA (µg), while isolation of RNA from HIV supernatants tends to yield much lower quantites (ng).
The computational portion of C-MFA relates the measured C-labeling patterns to metabolic fluxes by iterative least-squares regression.
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However, for all devices considered, significant performance improvements were obtained in the computational portions of the algorithm by giving up the generality of the double convolution loops and unrolling for specific kernel sizes.
The computational portions of the Materials and Methods are described in Additional file 9.
The computational portions of the MetaPhase method consist of software written in C++ using Boost (http://www.boost.org) with auxiliary scripts written in Perl and bash.
AM wrote the largest portion "Computational Procedure" subsection in the "Materials and Methods" section.
During unused Internet time, a central computer sends a portion of any given computational project to each participating PC, which transmits calculated results back to the main unit.
The present study aimed at investigating the binding properties of a set of 23 fibrates, characterized by similar carboxylic heads but differing in the size and orientation of the hydrophobic portion, using computational approaches.
DRR performed computational analyses and drafted portions of the manuscript.
The computational power available in such pools of computers can be vast, particularly in institutions such as Universities, which have thousands of computers serving as terminals for only a portion of the day.
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