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Even though some of these methods have computational gap filling methods, there is still a need for manual curation to obtain a functional model.
The sequence represents improved high-quality draft sequence (23 ) with no discernable misassembles having undergone multiple rounds of computational gap closure.
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For our models, gap-filling was initially performed using a computational gap-filling algorithm [ 27]-[ 30].
In addition, the automated computational gap-analyses (step 46 48 in stage 4) and gap-fill algorithms (step 51 58 in stage 4) are not incorporated in MicrobesFlux, although, for a medium-scale metabolic model, users can manually identify gaps (such as dead-end metabolites) and adjust the metabolic reactions to fill these gaps.
The term computation gap has been defined as the difference between the computational power demanded by the application domain and the computational power of the underlying computer platform.
According to the computation results of energy band, the computational value of energy gap (2.161 eV) is consistent with other computational results, though it is smaller than its experimental value (3.23 eV) (Fig. 4).
We demonstrate the existence of a gap in computational cost between two classes of problem instances.
The question is thus to bridge the gap between computational power and high security.
The performance gap and computational time is used to measure the performance of proposed model.
The authors acknowledge that TBI started from research done by a small group who found how to bridge the gap between computational biology and medicine.
To fill this gap, a computational framework, based on the finite element method, is proposed to simulate chemical reactions and diffusion processes occurring in EVA.
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