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Multiple computational criteria were used to select target mRNA regions likely to be single stranded and accessible to hhRz annealing and cleavage.
Together, these constraints constitute computational criteria for selecting those reactions that ensure a low redundancy on metabolite synthesis with a maximal effect for decreasing its phenotype.
Thus, this computational criteria lead us to identify a set of target enzymes whose metabolic activity may has a direct effect on cancer cell growth, see Figure 3.
Furthermore, based on pure computational criteria, we concluded that a set of enzymes (such as lactate dehydrogenase and pyruvate dehydrogenase) perform a pivotal role in cancer cell growth, findings supported by an experimental counterpart.
Furthermore, based on computational criteria we identified some enzymes with a relevant influence on cell growth and compared them with those considered as potential therapeutic targets in the literature.
GeneClass2 was also used to implement an assignment test with Bayesian computational criteria [ 29].
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The false discovery rate (FDR) criterion is then chosen to filter out the least significant genes, thus providing a computational criterion that permits us to determine which edge is to be included in the network.
The proposed approach allows fulfilling both accuracy and low computational burden criteria, providing similar accuracy than the three-dimensional finite element method but with much lower computational requirements.
Third, the performance results for modular imperative agent-based models violating the computational optimality criteria might be compared to that of other modeling techniques by directly using the formalism.
Taking the number of parameters (criterion 2) and the computational costs (criterion 3) into account, the Langevin model is the most suitable formalism to consider the effects of random fluctuations while still providing an acceptable performance.
To identify novel miRNAs in Drosophila melanogaster, we have combined a computational screen for generic ncRNAs using RNAz with stringent filtering criteria specifically targeting miRNA precursors.
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