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The present study is a computational attempt to describe the functional mechanism at the atomic level based on the x-ray structure.
In agreement with recent experimental observations, the present study is the first computational attempt to elucidate NMO-IgG binding at the molecular level, as well as a first effort toward a less elusive AQP4 druggability.
With the aim of controlling drug resistant Plasmodium falciparum, a computational attempt of designing novel adduct antimalarial drugs through the molecular docking method of combining chloroquine with five alkaloids, individually is presented.
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Starting with a listener-oriented categorisation of possible goals for speech modification, this review article summarises the extensive set of behavioural findings related to human speech modification, identifies which factors appear to be beneficial, and goes on to examine previous computational attempts to improve intelligibility in noise.
To reduce ADR-related morbidity and mortality, several computational attempts to identification potential ADRs have been made, including: I) generating various drug-related profiling (e.g., chemical profiling, cellular response profiling) to predict ADRs at different levels.
Most, if not all, of these computational methodologies attempt to model atomic-level interactions, and hence high-resolution structural characterization of the designed proteins is critical for evaluating the atomic-level accuracy of the underlying design force-fields.
Theoretical and computational neuroscience attempts to explain what that information might be.
Some approaches focus on broad computational efforts attempting to design bioactive molecules against any target, while others concentrate on the families of targets with common structural features or individual targets.
It is in this regard significant that recent work in computational modeling attempts to implement informal logic models of natural-language reasoning.
Computational studies attempting to simulate alterations in heart rate using as a basis the biophysical findings used here used an SA node/atrial model established and implemented on previous occasions (Lei et al. 2005).
Artificial neural networks (ANNs) are computational models that attempt to emulate the architecture of the human brain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com