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In particular, we take a close look at how the degree of multifunctionality (whether it is known or not) interacts with the computational assignment of functions to genes.
The taxonomic distribution of diazotrophs identified through computational assignment suggests that nitrogen fixation has greater biodiversity.
The results suggest that we have indeed succeeded in creating a quantitative method for computational assignment of hinge and shear mechanisms.
Motivation: The automated functional annotation of biological macromolecules is a problem of computational assignment of biological concepts or ontological terms to genes and gene products.
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Overall, these results corroborate the idea that unsupervised computational assignments can provide first approximations or working hypotheses that can be refined or verified in subsequent steps [ 11, 36].
Our computational assignments provide a good indication that these species are potential diazotrophs and give direction to experimentalists to validate these predictions.
To estimate the reliability of unsupervised computational assignments, we compared the September 2008 and September 2010 versions of GO annotation data for four representative Eukaryotes (Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster and Saccharomyces cerevisiae).
Confirmation of this computational gene assignment was then confirmed by manual inspection for the 211 CLK:BMAL1 peaks.
To determine if the computational and statistical assignment had any significant effect on the students' understanding of the biological material, we compared scores of the pre- and postlaboratory quizzes using a paired t test.
Indeed, we believe that there are no computational gene function assignments that can be shown to preclude the possibility they reflect only underlying multifunctionality.
Using fold recognition, we have identified highly confident computational 3D structural assignments for 21 Mimivirus ORFans.
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