Since the latter method allows for direct computation of the thresholds for all traits, whereas the simulation required significant computing time for each trait, we used the thresholds obtained using the effective number of markers.
Therefore, effect 1 is inherently included in the computation of the DR threshold.
This estimation incurs errors, which makes the computation of the Bayesian threshold be more conservative than the deterministic one.
Strictly speaking, the test statistic is χ-distributed, however, for large enough M, the CLT applies and so the distribution of the test statistic is approximated by a normal distribution which can simplify the computation of the appropriate threshold γ e such that the false alarm requirement is satisfied.
The following two sections describe the computation of the default threshold values.
As the most significant interval is guaranteed to be kept by this post-processing scheme, the FWER is unchanged and thus the computation of the significance threshold δ * is unaffected.
Therefore, due to the merit of the high precision rate and the reduction of computation cost, the threshold of unsupervised patterns is set to value 700 for the following experiments.
To include this potential bias in the computation of significance threshold, the null dataset was simulated to reflect the SNP selection process as follow: 600,000 polymorphic sites were simulated on 576 individuals.
Because of this, their H-threshold and H-amplitude values were not included in the computation of the mean H-threshold and H-amplitude of Group 2 patients.
The methodology is based on the computation of a reference threshold from the residue generated between the states of the system and the filter estimates such that when the residue takes values higher than this reference threshold the uncertain system is considered in fault.
