Based upon other studies where increased MRP2 may invoke resistance to cytotoxic drugs, it is reasonable to speculate that the elevated pCREB evident in mouse adenomas and CRC may also occur in human CRC and have a role in compromising the therapeutic impact of these drugs.
Vaccinating only individuals at lower risk for HIV would significantly diminish the impact of the vaccine, compromising the goal of controlling the epidemic.
As well as the physical consequences, there are also psychological ones, constituting what is known as the "post-fall syndrome", which include fear of another fall, and the loss of self-esteem and independence, compromising the patient's lifestyle and impacting on family caregivers.
The results of the implemented measures shows that the reduction potential identified by a LCA-analysis and implemented into daily business can lower the overall impact without substantially compromising the company economically.
The size of these groups was smaller than the minimum sample size estimated for the study, compromising the power to detect the expected impact.
The ability of the proposed method to detect fewer number of features without compromising the recognition performance can have a significant impact on the early detection and diagnosis of human diseases (eg glioma) using gene expressions.
Without intervention, the impact of these conditions is devastating, compromising the daily life of patients and their relatives.
Tolerances and assembly accuracies in critical areas could have a serious impact in the final performances, compromising the machine assembly and plasma operation.
However, this primary defect can have an impact on adjacent cell types, compromising the function of the epithelium as a whole.
